RESEARCH  STUDIES INTO THE ROLE AND FUNCTION OF THE KIDNEY IN HYPERTENSION, RENAL FAILURE AND OTHER CHRONIC DISEASES

Research is over a range of topics investigating the physiology and pharmacology of the kidney and heart.  Primary interest relate to neuro-humoral, paracrine and autocrine factors mediating the control of vascular and tubular function.  Our own studies in the intact kidney is one of the first in the world to show that at both the vasculature and tubules, the a1A- adrenoceptor is the dominant and functionally significant subtype in normotensive, stroke-prone spontaneously hypertensive, 2K1C Goldblatt and DOCA-salt hypertensive rat models. More recently, the involvement of various proteins(genes) in the pathogenesis of acute renal failure and diabetic nephropathy are being studied and the effects of antisense oligodeoxynucleotide for ICAM-1 (intracellular adhesion molecule-1) in a model of renal ischeamia reperfusion is also being investigated. We are also one of the early laboratories in this part of the world to embark on the role of stem cells in left ventricular hypertrophy and heart failure. 

Techniques routinely used for renal functional studies are electromagnetic flowmetry for measuring total renal blood flow and clearance studies for estimation of tubular reabsorptive function and antisense technology. Various models of rat hypertension and renal failure, diabetes, heart failure and others are produced in our own laboratory which is well furnished with state of art equipment in an Apple Macintosh and PC environment. 

The outcome of these studies will lead to a better understanding of the impact of these chronic diseases on the kidney function at the molecular and receptor levels and this knowledge can then be used to the development of novel drugs. 

Collaborators:

Local:

Associate Prof. Dr. Nor Azizan Abdullah

Department of Pharmacology, Medical Faculty, University Malaya 50603

Kuala Lumpur

 

International:

Professor Edward J Johns

Department of Physiology, University College Cork, College Road

Cork, Ireland 

 

 

Some related publications

 

Munavvar Abdul Sattar, N. A. Abdullah, A. H. Khan and A. M. Noor, (2004). Evaluation of anti-fungal and anti-bacterial activity of a local plant, Rhinacanthus nasustus (L). Journal of Biological Sciences 4 (4), 498-500. 

 

L. V. Kiew, Munavvar Abdul Sattar, C. H. Law, N. A. Abdullah, A. R. Nazarina, K. Sidik and E. J. Johns, (2004). Effect of antisense oligodeoxynucleotides for ICAM-1 on renal ischaemia-reperfusion injury in the anaesthetized rat. Journal of Physiology (London), 557.3, 981-989

       (University's Sanggar Sanjung Award for outstanding achievement in the publication category; 2004).

 

       A. Armenia, Munavvar Abdul Sattar, N. A. Abdullah, A. Helmi and E. J. Johns, (2004) The contribution of adrenoceptor subtype(s) in the renal vasculature of diabetic spontaneously hypertensive rats. British Journal of Pharmacology, 142, 719-726. 

 

       Muniandy P. Abdullah NA, A.S. Munavvar and Johns, E.J., (2004). Antisense Oligodeoxynecleotide to TGF-B1 improves renal function in STZ induced Diabetes. International Society of Nephrology conference on prevention and progression of renal diseases. P42009, June 29-July, Hong Kong. BEST POSTER AWARD. 

 

      .A. Abdullah, C.H. Law, L.V. Kiew, Munavvar Abdul Sattar, and Johns E.J., (2002). Effect of antisense oligodeoxynucleotides to TGF-b₁ on kidney function in a rat model of chronic renal failure. Pharmacologist, Vol.44, No.2, Suppl 1, 97.11, A160.  

 

      Munavvar Abdul Sattar, E. K. Gan, T. W. Sam and E. J. Johns, (2000). Acute renal failure in 2K2C Goldblatt hypertensive rats during antihypertensive therapy: comparison of angiotensin AT₁ receptor antagonist and clonidine analogues. Journal of Autonomic Pharmacology, 20, 297-304.

 

      E.M. Elssfah, K. Chinnakali, H.K. Fun, I.W. Mathison, E.K.Gan, Munavvar Abdul Sattar, T.W. Sam, and K.S. Khoo, (1999). 3,5-dichloro-4-(imidazolidin-2-ylidene-ammonio) benzoate

      dihydrate. Acta Cryst. C55, 1115-1117.  

      E.M. Elssfah, K. Chinnakali, H.K. Fun, I.W. Mathison, E.K. Gan, Munavvar Abdul Sattar, T.W. Sam, and K.S. Khoo, (1999). Substituted clonidine derivatives 111. 3,5-Dichloro-4-(imidazolidin-2-ylideneamino)benzyl alcohol and 3,5-dichloro-4-(1,3-diisobutyrylimidazolidin-2-ylideneamino) benzylisobutyrate. Acta Cryst. C55, IUC9900086.  

      E.M. Elssfah, K. Chinnakali, H.K. Fun, I.W. Mathison, E.K.Gan, Munavvar Abdul Sattar, T.W. Sam, and K.S. Khoo, (1999). Substituted clonidine derivatives 11. Ethyl 3,5-dichloro-4-(1-isobutyrylimidazolidin- 2-ylideneamino)benzoate and ethyl 3,5-dichloro-4- (1,3-diisobutyrylimidazolidin-2-ylideneamino) benzoate. Acta Cryst; C55, IUC9900085. 

      E.M. Elssfah, K. Chinnakali, H.K. Fun, I. W. Mathison, E. K. Gan, Munavvar Abdul Sattar, T. W. Sam and K. S. Khoo, (1999). Substituted clonidine derivatives I. 3,5-Dichloro-4-(imidazolidin-2-ylideneamino)benzonitrile and 3,5-dichloro-4-(1,3-diisobutyrylimidazolidin-2-ylideneamino)benzo-nitrile. ActaCryst; C55, IUC9900066. 

      Munavvar Abdul Sattar and E. J. Johns, (1996). Alpha-1 adrenoceptor subtypes involved in mediating adrenergically induced antinatriuresis and antidiuresis in two kidney, one clip Goldblatt and deoxycorticosterone acetate-salt hypretensive rats. The Journal of Pharmacology and Experimental Therapeutics, 277, 245-252.      

      Munavvar Abdul Sattar and E. J. Johns, (1995). The a1-adrenoceptor subtypes mediating adrenergically mediated antiidiuresis and antinatriuresis in the Wistar and stroke-prone spontaneously hypertensive rats. European Journal of Pharmacology, 294, 727-736. 

      Munavvar Abdul Sattar and E. J. Johns, (1994). The a1-adrenoceptor subtypes mediating adrenergic vasoconstriction in the kidney of the of the 2K1C Goldblatt and DOCA-salt hypertensive rats. Journal of Cardiovascular Pharmacology, 24, 420-428.

 

      Munavvar Abdul Sattar and E. J. Johns, (1994). Evidence for the a1-adrenoceptor subtypes mediating adrenergic vasoconstriction in the kidney in the of the Wistar and stroke-prone spontaneously hypertensive rats. Journal of Cardiovascular Pharmacology, 23, 232-239.