Studies
of the effects of isoniazid (INH) and its derivatives on
Mycobacterium avium NCTC 8559
Project
Summary
The
study aimed to elucidate the INH action at cellular level on
the growth cycle of
M. avium
strain NCTC 8559. The growth
stages were identified as the initial, filamentous and
fragmentation stages. The organism was found to be highly
resistant to INH with cells at the initial and fragmentation
stages being the most susceptible. In further susceptibility
studies using 9 hydrophobic alkyl derivatives of the parent
compound, only derivative 1-isonicicotinyl-2-nonanoyl
hydrazine showed enhanced antimicrobial activity.
